"ILX23-7553"^^ . "37861"^^ . "Ro23-7553CNNCI" . "ILX23-7553CNNCI" . "ILX23-7553"^^ . "ILX23-7553PTNCI-GLOSSCDR0000044892" . "C1883"^^ . "ILX23-7553"^^ . . . "Pharmacologic Substance"^^ . "ILX23-7553PTNCI" . . "C0966846"^^ . "A substance that is being studied as an anticancer drug.NCI-GLOSS" . "1,25-dihydroxy-16-ene-23-yne-cholecalciferolSNNCI" . "37861"^^ . "A vitamin D3 analogue with potential antineoplastic activity. ILX23-7553 binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor, this agent induces cancer cell differentiation, inhibits cancer cell growth and induces apoptosis. In addition, ILX23-7553 may also induce growth arrest and apoptosis independent of vitamin D receptor activation through mechanisms that are not fully elucidated.NCI" .