_:vb773014 _:vb691148 . _:vb634987 . _:vb773015 _:vb691149 . _:vb691147 . _:vb773016 _:vb691150 . _:vb691155 . . _:vb773017 _:vb691151 . _:vb745211 _:vb745212 . _:vb691152 . "SNDX-275PTNCI-GLOSSCDR0000630957" . _:vb773021 _:vb691155 . _:vb773020 _:vb691154 . "38294"^^ . "MS 27-275CNNCI" . "A substance being studied in the treatment of several types of cancer. It blocks enzymes needed for cell division and may kill cancer cells. It is a type of histone deacetylase (HDAC) inhibitor.NCI-GLOSS" . _:vb773019 _:vb691153 . "C1863"^^ . _:vb773018 _:vb691152 . "FDA"^^ . "1ZNY4FKK9H"^^ . _:vb773021 . "209783-80-2"^^ . _:vb634987 . _:vb634987 _:vb745211 . _:vb634989 . _:vb691154 . "C1510480"^^ . _:vb691153 . _:vb773018 . _:vb691155 . _:vb634988 . "SNDX-275CNNCI" . _:vb691152 . "Entinostat"^^ . _:vb691153 . "MS-275CNNCI" . "HDAC inhibitor SNDX-275PTNCI-GLOSSCDR0000635095" . "MS-275PTNCI-GLOSSCDR0000045014" . "EntinostatPTNCI" . "MS-275PTDCP31823" . "Pharmacologic Substance"^^ . "Hematologic cancer; lymphomas; solid tumors"^^ . "ENTINOSTATPTFDA1ZNY4FKK9H" . _:vb691152 . _:vb773015 _:vb773016 . _:vb691149 . . _:vb691147 . _:vb691153 . _:vb745211 _:vb634988 . _:vb773013 _:vb773014 . "MS-27-275"^^ . "Carbamic Acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3- pyridinylmethyl EsterSNNCI" . _:vb691154 . "Entinostat"^^ . _:vb691151 . "38294"^^ . _:vb745212 _:vb634989 . _:vb745212 . _:vb773014 _:vb773015 . _:vb691155 . _:vb634989 _:vb773019 . "706995"^^ . _:vb691150 . . "N-(2-Aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)aminomethyl]b enzamideSNNCI" . _:vb691151 . _:vb691148 . _:vb773019 _:vb773020 . "Carbamic acid, [[4-[[(2-aminophenyl)amino]carbonyl]phenyl] methyl]-, 3-pyridinylmethyl ester (9CI)SNNCI" . _:vb634988 _:vb773013 . _:vb691148 . _:vb773017 _:vb773018 . _:vb691149 . _:vb773016 _:vb773017 . _:vb691149 . _:vb691148 . . _:vb691150 . . _:vb691147 . "entinostatPTNCI-GLOSSCDR0000630959" . _:vb691151 . "A synthetic benzamide derivative with potential antineoplastic activity. Entinostat binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. This agent appears to exert dose-dependent effects in human leukemia cells including cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis. In normal cells, cyclin-dependent kinase inhibitor 1A expression has been associated with cell-cycle exit and differentiation.NCI" . "C21H20N4O3"^^ . _:vb773020 _:vb773021 . _:vb773013 _:vb691147 . _:vb691154 . _:vb691150 .