_:vb776180 _:vb776181 . _:vb696240 . "Organic Chemical"^^ . _:vb696236 . _:vb696241 . _:vb776181 _:vb776182 . _:vb776179 _:vb696235 . _:vb730669 . _:vb776178 _:vb696234 . _:vb776182 _:vb776183 . _:vb776185 . "[AElig]-941CNNCI" . "Unresectable Stage IIA or IIIB Non-Small Cell Lung Cancer; Advanced Solid Tumors; Metastatic Renal Cell Carcinoma Refractory to Immunotherapy; Early Relapse or Refractory Multiple Myeloma."^^ . _:vb776180 _:vb696236 . _:vb696237 . _:vb636098 . _:vb733374 _:vb730669 . "305838-77-1"^^ . . _:vb776181 _:vb696237 . . _:vb776182 _:vb696238 . _:vb733374 . _:vb696235 . _:vb696239 . "A substance made from shark cartilage that is being studied for its ability to prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.NCI-GLOSS" . _:vb776183 _:vb696239 . _:vb696238 . "A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity. Shark cartilage extract AE-941 competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cellular receptor, thereby inhibiting endothelial cell proliferation. This agent also inhibits matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and activates caspase-mediated apoptotic pathways in endothelial cells.NCI" . _:vb696234 . _:vb776184 _:vb776185 . _:vb696237 . _:vb696234 . . _:vb696234 . "Shark Cartilage Extract AE-941"^^ . _:vb730669 _:vb776178 . _:vb636098 _:vb733374 . _:vb696235 . _:vb696236 . "AE-941CNNCI" . "Shark Cartilage Extract AE-941PTNCI" . . "Pharmacologic Substance"^^ . "706456"^^ . _:vb696238 . _:vb696238 . _:vb696241 . _:vb696239 . . _:vb696235 . "42021"^^ . _:vb696236 . "Neovastat"^^ . _:vb696240 . "NeovastatBRNCI" . "C1963096"^^ . _:vb696240 . "C1798"^^ . _:vb776185 _:vb696241 . _:vb696237 . "NeovastatPTDCP31675" . "42021"^^ . "AE-941PTNCI-GLOSSCDR0000045103" . _:vb776179 _:vb776180 . _:vb696241 . _:vb776184 _:vb696240 . "Shark Cartilage Extract AE-941"^^ . _:vb696239 . _:vb776178 _:vb776179 . _:vb636098 . _:vb776183 _:vb776184 .