. "RG-12915CNNCI" . "Pharmacologic Substance"^^ . "RG_12915"^^ . "41268"^^ . "Organic Chemical"^^ . "RG 12915CNNCI" . . "RG 12915"^^ . "RG 12915"^^ . "125363-06-6"^^ . "C1525"^^ . "RG12915CNNCI" . "C0246228"^^ . "A 5-hydroxytryptamine-3 (5-HT3) receptor antagonist with antiemetic activity. RG 12915 binds to and antagonizes the action of serotonin on the 5-HT-3 receptor located on vagal afferents in the chemoreceptor trigger zone (CTZ), resulting in suppression of chemotherapy-induced nausea and vomiting.NCI" . "41268"^^ . . "RG 12915PTNCI" .