<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>DCP</n0:term-source><n0:source-code>01195</n0:source-code></n0:ComplexTerm>" . _:vb718858 <http://www.w3.org/2002/07/owl#someValuesFrom> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17573> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P366> "Tacrolimus"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P319> "WM0HAQ4WNM"^^<http://www.w3.org/2001/XMLSchema#string> . _:vb718860 <http://www.w3.org/2002/07/owl#onProperty> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R122> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://www.w3.org/2000/01/rdf-schema#subClassOf> _:vb718858 . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://www.w3.org/2000/01/rdf-schema#subClassOf> _:vb718859 . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://www.w3.org/2000/01/rdf-schema#subClassOf> _:vb718860 . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P207> "C0085149"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>FK 506</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P108> "Tacrolimus"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://www.w3.org/2002/07/owl#sameAs> <http://linked.opendata.cz/resource/ndfrt/ingredient/N0000007302> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Fujimycin</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P175> "717865"^^<http://www.w3.org/2001/XMLSchema#string> . _:vb718860 <http://www.w3.org/2002/07/owl#someValuesFrom> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C46000> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://www.w3.org/2000/01/rdf-schema#subClassOf> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C574> . _:vb718859 <http://www.w3.org/2002/07/owl#someValuesFrom> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45999> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone</n0:term-name><n0:term-group>SN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P330> "42009"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P302> "Atopic dermatitis; Kidney transplant rejection, prophylaxis; Liver transplant rejection, prophylaxis"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Protopic</n0:term-name><n0:term-group>BR</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://linked.opendata.cz/ontology/mesh/hasConcept> <http://linked.opendata.cz/resource/mesh/concept/M0025261> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#code> "C1311"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P97> "<n0:ComplexDefinition xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:def-definition>A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P350> "C44H69NO12.H2O"^^<http://www.w3.org/2001/XMLSchema#string> . _:vb718859 <http://www.w3.org/2002/07/owl#onProperty> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R122> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>tacrolimus</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000045414</n0:source-code></n0:ComplexTerm>" . _:vb718858 <http://www.w3.org/2002/07/owl#onProperty> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R122> . _:vb718858 <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Restriction> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Class> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P106> "Antibiotic"^^<http://www.w3.org/2001/XMLSchema#string> . _:vb718859 <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Restriction> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#A8> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://www.w3.org/2000/01/rdf-schema#label> "Tacrolimus"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P322> "FDA"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P368> "CHEBI:61057"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Tacrolimus</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>TACROLIMUS</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>FDA</n0:term-source><n0:source-code>WM0HAQ4WNM</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P303> "Graft versus Host Disease, prevention; Kidney transplantation rejection, prevention"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Prograf</n0:term-name><n0:term-group>BR</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P329> "42009"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://www.w3.org/2002/07/owl#sameAs> <http://linked.opendata.cz/resource/fda-spl/ingredient/WM0HAQ4WNM> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P325> "<n0:ComplexDefinition xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:def-definition>A drug used to help reduce the risk of rejection by the body of organ and bone marrow transplants.</n0:def-definition><n0:def-source>NCI-GLOSS</n0:def-source></n0:ComplexDefinition>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Tacrolimus</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>DTP</n0:term-source><n0:source-code>NSC0717865</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P106> "Organic Chemical"^^<http://www.w3.org/2001/XMLSchema#string> . _:vb718860 <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Restriction> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://www.w3.org/2000/01/rdf-schema#subClassOf> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2201> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1311> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P210> "109581-93-3"^^<http://www.w3.org/2001/XMLSchema#string> .