"129298-91-5"^^ . "(3R,4S,5S,6R)-5-Methoxy-4- [(2R,3R)-2-methyl-3-(3-methyl-2-butenyl) -oxiranyl]-1-oxaspiro [2,5] oct-6-yl(chloroacetyl) CarbamateSNNCI" . "41725"^^ . "O-Chloroacetylcarbamoylfumagillol"^^ . "Pharmacologic Substance"^^ . "O-Chloroacetylcarbamoylfumagillol"^^ . "AGM-1470SYDTPNSC0642492" . "41725"^^ . "A substance being studied in the treatment of cancer. It may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.NCI-GLOSS" . "642492"^^ . "C1298"^^ . . "TNP-470PTNCI-GLOSSCDR0000045394" . "Organic Chemical"^^ . . "TNP-470SYDTPNSC0642492" . "[3R-[3alpha,4alpha(2R*,3R*),5beta,6beta]]-5-Methoxy-4-[2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl (chloroacetyl)carbamatePTDCP09176" . "A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds to and irreversibly inactivates methionine aminopeptidase-2 (MetAP2), resulting in endothelial cell cycle arrest late in the G1 phase and inhibition of tumor angiogenesis. This agent may also induce the p53 pathway, thereby stimulating the production of cyclin-dependent kinase inhibitor p21 and inhibiting angiogenesis. (NCI04)NCI" . . . "TNP-470"^^ . "O-ChloroacetylcarbamoylfumagillolPTNCI" . "C0081489"^^ . "TNP-470CNNCI" . "5-Methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)-1-oxaspiro(2,5)oct-6-yl(chloroacetyl)carbamateSNNCI" . "AGM-1470CNNCI" .