"Pharmacologic Substance"^^ . "Brain Tumors."^^ . "172112"^^ . . "Spirohydantoin mustardSYDTPNSC0172112" . "39441"^^ . "Spiromustine"^^ . "C1233"^^ . . "SHMABNCI" . "56605-16-4"^^ . "Organic Chemical"^^ . "Spirohydantoin MustardSYNCI" . "C0075019"^^ . "SpiromustinePTNCI" . "Spiromustine"^^ . . "1,3-diazaspiro(4,5)decane-2,4-dione,3-(2-(bis-chloroethyl)amino)ethylSNNCI" . "39441"^^ . "A bifunctional nitrogen alkylating agent with antineoplastic activity and lipophilic properties. Containing a lipophilic hydantoin group that serves as a carrier to cross the blood brain barrier, spiromustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)NCI" . "Spiromustine"^^ .