<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://www.w3.org/2000/01/rdf-schema#subClassOf> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C261> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://www.w3.org/2002/07/owl#sameAs> <http://linked.opendata.cz/resource/fda-spl/ingredient/W36ZG6FT64> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P210> "53123-88-9"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://www.w3.org/2000/01/rdf-schema#subClassOf> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C574> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Class> . _:vb712653 <http://www.w3.org/2002/07/owl#onProperty> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R122> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>WY-090217</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Rapamycin</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P322> "FDA"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P97> "<n0:ComplexDefinition xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:def-definition>A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04)</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>" . _:vb712652 <http://www.w3.org/2002/07/owl#onProperty> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R122> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P366> "Sirolimus"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P303> "Acute leukemia; Glioblastoma multiforme; Graft-versus-host disease; Kidney transplantation; Liver transplantation; Membranous glomerulonephritis; Multiple sclerosis; Non-Hodgkins lymphoma"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#code> "C1212"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Sirolimus</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>DCP</n0:term-source><n0:source-code>20504</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>rapamycin</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000285947</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P329> "42555"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#A8> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>SILA 9268A</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>AY 22989</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>sirolimus</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000045513</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,2</n0:term-name><n0:term-group>SN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P207> "C0072980"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P325> "<n0:ComplexDefinition xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:def-definition>A drug used to keep the body from rejecting organ and bone marrow transplants. Rapamune blocks certain white blood cells that can reject foreign tissues and organs. It also blocks a protein that is involved in cell division. It is a type of antibiotic, a type of immunosuppressant, and a type of serine/threonine kinase inhibitor. Rapamune was previously called rapamycin.</n0:def-definition><n0:def-source>NCI-GLOSS</n0:def-source></n0:ComplexDefinition>" . _:vb712651 <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Restriction> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P106> "Antibiotic"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>RAPA</n0:term-name><n0:term-group>AB</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P330> "42555"^^<http://www.w3.org/2001/XMLSchema#string> . _:vb712651 <http://www.w3.org/2002/07/owl#onProperty> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R122> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>RAPAMYCIN</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>DTP</n0:term-source><n0:source-code>NSC0226080</n0:source-code></n0:ComplexTerm>" . _:vb712653 <http://www.w3.org/2002/07/owl#someValuesFrom> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45999> . _:vb712651 <http://www.w3.org/2002/07/owl#someValuesFrom> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C46000> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://linked.opendata.cz/ontology/mesh/hasConcept> <http://linked.opendata.cz/resource/mesh/concept/M0029863> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P108> "Sirolimus"^^<http://www.w3.org/2001/XMLSchema#string> . _:vb712652 <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Restriction> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://www.w3.org/2002/07/owl#sameAs> <http://linked.opendata.cz/resource/ndfrt/ingredient/N0000006605> . _:vb712652 <http://www.w3.org/2002/07/owl#someValuesFrom> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17573> . _:vb712653 <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Restriction> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Rapamune</n0:term-name><n0:term-group>BR</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P302> "Kidney transplant rejection, prevention"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P368> "CHEBI:9168"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P319> "W36ZG6FT64"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Sirolimus</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P106> "Carbohydrate"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>SIROLIMUS</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>FDA</n0:term-source><n0:source-code>W36ZG6FT64</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P350> "C51H79NO13"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://www.w3.org/2000/01/rdf-schema#subClassOf> _:vb712652 . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://www.w3.org/2000/01/rdf-schema#subClassOf> _:vb712653 . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Rapamune</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000580375</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P175> "226080"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://www.w3.org/2000/01/rdf-schema#subClassOf> _:vb712651 . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212> <http://www.w3.org/2000/01/rdf-schema#label> "Sirolimus"^^<http://www.w3.org/2001/XMLSchema#string> .