"FDA"^^ . . "A synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1). The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.NCI" . "OltiprazSYDTPNSC0347901" . "64224-21-1"^^ . "oltiprazPTNCI-GLOSSCDR0000045406" . "3H-1,2-Dithiole-3-thione,4-methyl-5-pyrazinylSNNCI" . "41866"^^ . "3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl-SYDTPNSC0347901" . "C8H6N2S3"^^ . "OLTIPRAZPTFDA6N510JUL1Y" . "347901"^^ . "A drug used in cancer prevention.NCI-GLOSS" . "Oltipraz"^^ . "6N510JUL1Y"^^ . "Pharmacologic Substance"^^ . "RP-35,972ABNCI" . "4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thioneSNNCI" . "Oltipraz"^^ . . . "Organic Chemical"^^ . "C0069456"^^ . "5-[2-Pyrazinyl]-4-methyl-1,2-3-thioneSNNCI" . "Oltipraz"^^ . "41866"^^ . "5-(2-Pyrazinyl)-4-methyl-1,2-dithiol-3-thioneSNNCI" . . . . "4-Methyl-5-(pyrazinyl)-3H-1,2-dithiole-3-thioneSNNCI" . "OltiprazPTNCI" . "OltiprazPTDCP00071" . "C1177"^^ .