. . "Olsalazine"^^ . "ULS5I8J03O"^^ . "3,3'-Dicarboxy-4,4'-dihydroxyazobenzeneSNNCI" . . . "41828"^^ . "15722-48-2"^^ . "Pharmacologic Substance"^^ . "AzodisalicylateSYNCI" . "Organic Chemical"^^ . "OLSALAZINEPTFDAULS5I8J03O" . . "C14H10N2O6"^^ . "3,3'-Azobis[6-hydroxybenzoic Acid]SNNCI" . "A prodrug of mesalamine (5-Aminosalicylic acid; 5-ASA) with anti-inflammatory activity. Unabsorbed olsalazine passes through gastrointestinal tract and is cleaved by azoreductases, produced by microflora in colon, into 2 active molecules of 5-ASA. 5-ASA exerts its anti-inflammatory action locally by inhibiting cyclooxygenase and lipoxygenase activities, thereby reducing the production of prostaglandins and leukotrienes. In addition, mesalamine may act as a scavenger of reactive oxygen free radicals.NCI" . "3,3'-Azobis[6-hydroxybenzoic Acid]PTDCP00801" . "41828"^^ . "CHEBI:7770"^^ . "Olsalazine"^^ . "FDA"^^ . "Olsalazine"^^ . "OlsalazinePTNCI" . "C.I. Mordant Yellow 5SYNCI" . "C1176"^^ . "C0069454"^^ . . "Ulcerative colitis"^^ .