"Lauryl monoethoxylate"@en . "When administered, polidocanol locally damages blood vessel endothelium. Following the endothelial damage, platelets aggregate at the site and attach to the venous wall eventually resulting in a dense network of platelets, cellular debris, and fibrin that occludes the vessel. Eventually the vessel is replaced by connective fibrous tissue."@en . "Ethylene glycol mono-N-dodecyl ether"@en . "Hydroxyl polyethoxy dodecane"@en . "Polidocanol"@en . . . . . . "approved"@en . . "Most adverse reactions are related to the intravenous administration such as local irritation, pain, and hematoma. Extravasation can also be an issue."@en . . . . "9002-92-0"@en . "When given intravenously, the volume of distribution was 35-82L."@en . . "Ethylene glycol monolauryl ether"@en . . . . . . . . "Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins and uncomplicated reticular veins in the lower extremity. "@en . . . "Lauromacrogol"@en . . "Humans and other mammals"@en . "2-Hydroxyethyl lauryl ether"@en . "When given intravenously, the maximum blood concentrations were reached in 15 mins."@en . "Plasma protein binding was not measured."@en . "Laureth 9"@en . . "Macrogol lauryl ether"@en . "# Peterson JD, Goldman MP, Weiss RA, Duffy DM, Fabi SG, Weiss MA, Guiha I: Treatment of reticular and telangiectatic leg veins: double-blind, prospective comparative trial of polidocanol and hypertonic saline. Dermatol Surg. 2012 Aug;38(8):1322-30. doi: 10.1111/j.1524-4725.2012.02422.x. Epub 2012 May 23. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/22620717 # Weiss RA, Voigts R, Howell DJ: Absence of Concentration Congruity in Six Compounded Polidocanol Samples Obtained for Leg Sclerotherapy. Dermatol Surg. 2011 Mar 17. doi: 10.1111/j.1524-4725.2011.01906.x. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/21414067 # http://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_113.pdf # FDA label. # Lexicomp."@en . . . . . "Route of elimination was not indicated."@en . "Sytemic clearance was 0.2-0.4 L/min."@en . . " "@en . "PEG-9 lauryl alcohol "@en . "Polydocanol"@en . "The half-life is approximately 1.5 h. "@en . . . . "Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins (varicose veins \u22641 mm in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity. It is marketed under the brand names Asclera and Varithena."@en . . . . . . . . . . . . "Oxypolyethoxydodecane"@en . "Lauryl ethoxylate"@en . "Dodecylpolyethyleneglycolether"@en . . . "POE-9 lauryl alcohol"@en . . .