. . . . . . . "N,N,N',N'-tetraethylthiuram disulfide"@en . . . "LD₅₀=8.6g/kg (orally in rats). Symptoms of overdose include irritation, slight drowsiness, unpleasant taste, mild GI disturbances, and orthostatic hypotension."@en . . "A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase. [PubChem]"@en . . . "Antabuse (tn)"@en . . . . . " "@en . "Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage during alcohol metabolism following disulfiram intake causing an accumulation of acetaldehyde in the blood producing highly unpleasant symptoms. Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase, which acts in the second step of ethanol utilization. In addition, disulfiram competitively binds and inhibits the peripheral benzodiazepine receptor, which may indicate some value in the treatment of the symptoms of alcohol withdrawal, however this activity has not been extensively studied."@en . "97-77-8"@en . "For the treatment and management of chronic alcoholism"@en . . . . "Tetraethylthiuram Disulfide"@en . . . . . "1,1'-dithiobis(N,N-diethylthioformamide)"@en . . . . . . . . . . "Tetraethylthioperoxydicarbonic Diamide"@en . . . . "Bis(diethylthiocarbamoyl) disulfide"@en . . . . . . . . . . . . "Tetraethylthiuram Disulphide"@en . . . "Adams, H.S. and Meuser, L.; US.Patent 1,782,111; November 18,1930; assigned to The Naugatuck Chemical Company. Bailey, G.C.; U.S.Patent 1,796,977; March 17,1931; assigned to The Roessler & Hasslacher Chemical Company."@en . . . "Disulfiram"@en . "approved"@en . . "Humans and other mammals"@en . . . "# Nash T, Rice WG: Efficacies of zinc-finger-active drugs against Giardia lamblia. Antimicrob Agents Chemother. 1998 Jun;42(6):1488-92. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/9624499 # Bouma MJ, Snowdon D, Fairlamb AH, Ackers JP: Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus. J Antimicrob Chemother. 1998 Dec;42(6):817-20. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/10052908 # Gaval-Cruz M, Weinshenker D: mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse. Mol Interv. 2009 Aug;9(4):175-87. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/ 19720750"@en . . . . . "Take without regard to meals."@en . "Avoid alcohol for up to 14 days after treatment has been stopped."@en . . "Disulfiram"@en . . . "Disulfiram is absorbed slowly from the gastrointestinal tract (80 to 90% of oral dose)."@en . . . . . .