. "For the treatment and the management of acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion."@en . . . "Cimetidine binds to an H₂-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity."@en . . . . . . . . "# Michnovicz JJ, Galbraith RA: Cimetidine inhibits catechol estrogen metabolism in women. Metabolism. 1991 Feb;40(2):170-4. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/1988774"@en . . . . . . "Rapid 60-70%"@en . "Cimetag"@en . . . . . . "Cim\u00E9tidine"@en . "Limit caffeine intake."@en . . "2-Cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine"@en . "Ulcerfen"@en . "51481-61-9"@en . . . . . . . . "N-Cyano-n'-methyl-n''-(2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidine"@en . . . . . . . . . . . . . . "1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine"@en . . . . . . . . "Cimetidinum"@en . . "The principal route of excretion of cimetidine is the urine."@en . . . . . . . . . . . . . . . . . "Humans and other mammals"@en . . . . . . . . . "approved"@en . . . . "N''-cyano-N-methyl-n'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine"@en . "Best effect when taken with food."@en . . . " "@en . "Avoid alcohol."@en . "Tagamet hb 200"@en . "Cimetidin"@en . "Symptoms of overdose include nausea, vomiting, diarrhea, increased saliva production, difficulty breathing, and a fast heartbeat."@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Cimetidine"@en . . . . "15-20%"@en . . "A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy. [PubChem]"@en . . . . . . "2 hours"@en . . . . . "Cimetidina"@en . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Saburo Uchikuga, Tomoyasu Tashiro, Yasuko Osawa, \"Process for preparing the H.sub.2 -receptor antagonist cimetidine.\" U.S. Patent US4413129, issued March, 1972."@en . . . . . . . " "@en . . .