<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>An angiogenesis inhibitor that acts by blocking the action of endothelial integrins. An endothelial-specific integrin/survival signaling inhibitor binds to and blocks the activity of endothelial-specific integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>