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Namespace Prefixes

Prefix	IRI
n6	http://linked.opendata.cz/resource/mesh/concept/
rdfs	http://www.w3.org/2000/01/rdf-schema#
rdf	http://www.w3.org/1999/02/22-rdf-syntax-ns#
n5	http://linked.opendata.cz/ontology/mesh/
owl	http://www.w3.org/2002/07/owl#
nci	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#
xsdh	http://www.w3.org/2001/XMLSchema#

Statements

Subject Item: nci:C1863
rdf:type: owl:Class
rdfs:label: Entinostat
rdfs:subClassOf: _:vb634987 nci:C1946
nci:A7: nci:C16682
nci:A8: nci:C63923
nci:P106: Pharmacologic Substance
nci:P108: Entinostat
nci:P175: 706995
nci:P207: C1510480
nci:P210: 209783-80-2
nci:P303: Hematologic cancer; lymphomas; solid tumors
nci:P319: 1ZNY4FKK9H
nci:P322: FDA
nci:P325: <n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A substance being studied in the treatment of several types of cancer. It blocks enzymes needed for cell division and may kill cancer cells. It is a type of histone deacetylase (HDAC) inhibitor.</n0:def-definition><n0:def-source>NCI-GLOSS</n0:def-source></n0:ComplexDefinition>
nci:P329: 38294
nci:P330: 38294
nci:P350: C21H20N4O3
nci:P366: MS-27-275
nci:P90: <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>SNDX-275</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000630957</n0:source-code></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>MS 27-275</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>SNDX-275</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>MS-275</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>HDAC inhibitor SNDX-275</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000635095</n0:source-code></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>MS-275</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000045014</n0:source-code></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Entinostat</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>MS-275</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>DCP</n0:term-source><n0:source-code>31823</n0:source-code></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>ENTINOSTAT</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>FDA</n0:term-source><n0:source-code>1ZNY4FKK9H</n0:source-code></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Carbamic Acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3- pyridinylmethyl Ester</n0:term-name><n0:term-group>SN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>N-(2-Aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)aminomethyl]b enzamide</n0:term-name><n0:term-group>SN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Carbamic acid, [[4-[[(2-aminophenyl)amino]carbonyl]phenyl] methyl]-, 3-pyridinylmethyl ester (9CI)</n0:term-name><n0:term-group>SN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>entinostat</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000630959</n0:source-code></n0:ComplexTerm>
nci:P97: <n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A synthetic benzamide derivative with potential antineoplastic activity. Entinostat binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. This agent appears to exert dose-dependent effects in human leukemia cells including cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis. In normal cells, cyclin-dependent kinase inhibitor 1A expression has been associated with cell-cycle exit and differentiation.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>
nci:code: C1863
n5:hasConcept: n6:M0304185

Subject Item: _:vb634987
rdf:type: owl:Class
owl:unionOf: _:vb745211

Subject Item: _:vb634988
rdf:type: owl:Class
owl:intersectionOf: _:vb773013

Subject Item: _:vb634989
rdf:type: owl:Class
owl:intersectionOf: _:vb773019

Subject Item: _:vb691147
rdf:type: owl:Restriction
owl:onProperty: nci:R146
owl:someValuesFrom: nci:C16682

Subject Item: _:vb691148
rdf:type: owl:Restriction
owl:onProperty: nci:R124
owl:someValuesFrom: nci:C40577

Subject Item: _:vb691149
rdf:type: owl:Restriction
owl:onProperty: nci:R125
owl:someValuesFrom: nci:C18824

Subject Item: _:vb691150
rdf:type: owl:Restriction
owl:onProperty: nci:R125
owl:someValuesFrom: nci:C40738

Subject Item: _:vb691151
rdf:type: owl:Restriction
owl:onProperty: nci:R125
owl:someValuesFrom: nci:C40800

Subject Item: _:vb691152
rdf:type: owl:Restriction
owl:onProperty: nci:R125
owl:someValuesFrom: nci:C21050

Subject Item: _:vb691153
rdf:type: owl:Restriction
owl:onProperty: nci:R124
owl:someValuesFrom: nci:C40502

Subject Item: _:vb691154
rdf:type: owl:Restriction
owl:onProperty: nci:R125
owl:someValuesFrom: nci:C17557

Subject Item: _:vb691155
rdf:type: owl:Restriction
owl:onProperty: nci:R125
owl:someValuesFrom: nci:C45524

Subject Item: _:vb745211
rdf:first: _:vb634988
rdf:rest: _:vb745212

Subject Item: _:vb745212
rdf:first: _:vb634989
rdf:rest: rdf:nil

Subject Item: _:vb773013
rdf:first: _:vb691147
rdf:rest: _:vb773014

Subject Item: _:vb773014
rdf:first: _:vb691148
rdf:rest: _:vb773015

Subject Item: _:vb773015
rdf:first: _:vb691149
rdf:rest: _:vb773016

Subject Item: _:vb773016
rdf:first: _:vb691150
rdf:rest: _:vb773017

Subject Item: _:vb773017
rdf:first: _:vb691151
rdf:rest: _:vb773018

Subject Item: _:vb773018
rdf:first: _:vb691152
rdf:rest: rdf:nil

Subject Item: _:vb773019
rdf:first: _:vb691153
rdf:rest: _:vb773020

Subject Item: _:vb773020
rdf:first: _:vb691154
rdf:rest: _:vb773021

Subject Item: _:vb773021
rdf:first: _:vb691155
rdf:rest: rdf:nil