HTML Microdata document

This HTML5 document contains 72 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

Prefix	IRI
n5	http://linked.opendata.cz/resource/mesh/concept/
rdfs	http://www.w3.org/2000/01/rdf-schema#
rdf	http://www.w3.org/1999/02/22-rdf-syntax-ns#
n4	http://linked.opendata.cz/ontology/mesh/
owl	http://www.w3.org/2002/07/owl#
nci	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#
xsdh	http://www.w3.org/2001/XMLSchema#

Statements

Subject Item: nci:C1798
rdf:type: owl:Class
rdfs:label: Shark Cartilage Extract AE-941
owl:equivalentClass: _:vb636098
nci:A7: nci:C16995 nci:C28496 nci:C18164
nci:P106: Organic Chemical Pharmacologic Substance
nci:P108: Shark Cartilage Extract AE-941
nci:P175: 706456
nci:P207: C1963096
nci:P210: 305838-77-1
nci:P303: Unresectable Stage IIA or IIIB Non-Small Cell Lung Cancer; Advanced Solid Tumors; Metastatic Renal Cell Carcinoma Refractory to Immunotherapy; Early Relapse or Refractory Multiple Myeloma.
nci:P325: <n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A substance made from shark cartilage that is being studied for its ability to prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.</n0:def-definition><n0:def-source>NCI-GLOSS</n0:def-source></n0:ComplexDefinition>
nci:P329: 42021
nci:P330: 42021
nci:P366: Neovastat
nci:P90: <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>[AElig]-941</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>AE-941</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Shark Cartilage Extract AE-941</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Neovastat</n0:term-name><n0:term-group>BR</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Neovastat</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>DCP</n0:term-source><n0:source-code>31675</n0:source-code></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>AE-941</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000045103</n0:source-code></n0:ComplexTerm>
nci:P97: <n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity. Shark cartilage extract AE-941 competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cellular receptor, thereby inhibiting endothelial cell proliferation. This agent also inhibits matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and activates caspase-mediated apoptotic pathways in endothelial cells.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>
nci:code: C1798
n4:hasConcept: n5:M0522005

Subject Item: _:vb636098
rdf:type: owl:Class
owl:intersectionOf: _:vb733374

Subject Item: _:vb696234
rdf:type: owl:Restriction
owl:onProperty: nci:R72
owl:someValuesFrom: nci:C13053

Subject Item: _:vb696235
rdf:type: owl:Restriction
owl:onProperty: nci:R146
owl:someValuesFrom: nci:C18164

Subject Item: _:vb696236
rdf:type: owl:Restriction
owl:onProperty: nci:R146
owl:someValuesFrom: nci:C28496

Subject Item: _:vb696237
rdf:type: owl:Restriction
owl:onProperty: nci:R124
owl:someValuesFrom: nci:C40577

Subject Item: _:vb696238
rdf:type: owl:Restriction
owl:onProperty: nci:R124
owl:someValuesFrom: nci:C40703

Subject Item: _:vb696239
rdf:type: owl:Restriction
owl:onProperty: nci:R125
owl:someValuesFrom: nci:C26044

Subject Item: _:vb696240
rdf:type: owl:Restriction
owl:onProperty: nci:R125
owl:someValuesFrom: nci:C17557

Subject Item: _:vb696241
rdf:type: owl:Restriction
owl:onProperty: nci:R125
owl:someValuesFrom: nci:C40579

Subject Item: _:vb730669
rdf:first: nci:C1970
rdf:rest: _:vb776178

Subject Item: _:vb733374
rdf:first: nci:C1742
rdf:rest: _:vb730669

Subject Item: _:vb776178
rdf:first: _:vb696234
rdf:rest: _:vb776179

Subject Item: _:vb776179
rdf:first: _:vb696235
rdf:rest: _:vb776180

Subject Item: _:vb776180
rdf:first: _:vb696236
rdf:rest: _:vb776181

Subject Item: _:vb776181
rdf:first: _:vb696237
rdf:rest: _:vb776182

Subject Item: _:vb776182
rdf:first: _:vb696238
rdf:rest: _:vb776183

Subject Item: _:vb776183
rdf:first: _:vb696239
rdf:rest: _:vb776184

Subject Item: _:vb776184
rdf:first: _:vb696240
rdf:rest: _:vb776185

Subject Item: _:vb776185
rdf:first: _:vb696241
rdf:rest: rdf:nil