This HTML5 document contains 81 embedded RDF statements represented using HTML+Microdata notation.

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Namespace Prefixes

PrefixIRI
n6http://linked.opendata.cz/resource/mesh/concept/
rdfshttp://www.w3.org/2000/01/rdf-schema#
n7http://linked.opendata.cz/resource/fda-spl/ingredient/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n5http://linked.opendata.cz/ontology/mesh/
owlhttp://www.w3.org/2002/07/owl#
ncihttp://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#
n4http://linked.opendata.cz/resource/ndfrt/ingredient/
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
nci:C1526
rdf:type
owl:Class
rdfs:label
Docetaxel
owl:equivalentClass
_:vb632020
nci:A7
nci:C18115 nci:C20450 nci:C17219
nci:A8
nci:C63923
nci:P106
Pharmacologic Substance Organic Chemical
nci:P108
Docetaxel
nci:P175
628503
nci:P207
C0246415
nci:P210
148408-66-6
nci:P302
Breast cancer; Esophageal cancer; Gastric cancer; Head/Neck cancers; Locally Advanced or Metastatic Non small-cell lung cancer; Ovarian cancer; Metastatic Prostate cancer
nci:P303
Acute lymphoblastic leukemia; Acute myeloid leukemia; Breast cancer; Cervical cancer; Chondrosarcoma; Esophageal cancer; Ewing's sarcoma; Gastric cancer; Head and Neck cancer; Colorectal cancer; Solid tumors Non-Small-Cell Lung cancer; Osteosarcoma; Ovarian cancer; Pancreatic cancer; Penile cancer; Prostate cancer; Breast cancer; Cervical cancer; Fallopian tube cancer; Peritoneal cavity cancer; Endometrial cancer
nci:P319
15H5577CQD
nci:P322
FDA
nci:P325
<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A drug used together with other drugs to treat certain types of breast cancer, stomach cancer, prostate cancer, and certain types of head and neck cancer. It is also being studied in the treatment of other types of cancer. Docetaxel is a type of mitotic inhibitor.</n0:def-definition><n0:def-source>NCI-GLOSS</n0:def-source></n0:ComplexDefinition>
nci:P329
41657
nci:P330
41657
nci:P350
C43H53NO14.3H2O
nci:P366
Docetaxel
nci:P368
CHEBI:59809
nci:P90
<n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>DOCETAXEL</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>FDA</n0:term-source><n0:source-code>15H5577CQD</n0:source-code></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Docetaxel</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>DCP</n0:term-source><n0:source-code>32090</n0:source-code></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Docetaxel</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Taxotere Injection Concentrate</n0:term-name><n0:term-group>BR</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>RP56976</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Taxotere</n0:term-name><n0:term-group>BR</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>docetaxel</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000045382</n0:source-code></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol</n0:term-name><n0:term-group>SN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Taxotere</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>DTP</n0:term-source><n0:source-code>NSC0628503</n0:source-code></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>Taxotere</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000508678</n0:source-code></n0:ComplexTerm> <n0:ComplexTerm xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:term-name>[2aR-[2a alphaa,4beta,4a beta,6beta,9alpha,(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-[[(1,1-dimethylethoxy)carbonyl]-amino]-alpha-hydroxybenzemepropanoic Acid 12b-(Acetyloxy)-12(benzyloxy)-2a,3,4,4a,5,6,8,10,11,12,12a,12b-dodecahydeo-4,-6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester</n0:term-name><n0:term-group>SN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>
nci:P97
<n0:ComplexDefinition xmlns:n0="http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#"><n0:def-definition>A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04)</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>
nci:code
C1526
owl:sameAs
n4:N0000005739 n7:15H5577CQD
n5:hasConcept
n6:M0184558
Subject Item
_:vb632020
rdf:type
owl:Class
owl:intersectionOf
_:vb730823
Subject Item
_:vb667058
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owl:onProperty
nci:R146
owl:someValuesFrom
nci:C17219
Subject Item
_:vb667059
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owl:onProperty
nci:R125
owl:someValuesFrom
nci:C17557
Subject Item
_:vb667060
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owl:onProperty
nci:R125
owl:someValuesFrom
nci:C19829
Subject Item
_:vb667061
rdf:type
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owl:onProperty
nci:R125
owl:someValuesFrom
nci:C40777
Subject Item
_:vb667062
rdf:type
owl:Restriction
owl:onProperty
nci:R122
owl:someValuesFrom
nci:C17573
Subject Item
_:vb667063
rdf:type
owl:Restriction
owl:onProperty
nci:R122
owl:someValuesFrom
nci:C45999
Subject Item
_:vb667064
rdf:type
owl:Restriction
owl:onProperty
nci:R122
owl:someValuesFrom
nci:C46000
Subject Item
_:vb730823
rdf:first
nci:C67437
rdf:rest
_:vb730825
Subject Item
_:vb730825
rdf:first
nci:C1490
rdf:rest
_:vb758290
Subject Item
_:vb758290
rdf:first
_:vb667058
rdf:rest
_:vb758291
Subject Item
_:vb758291
rdf:first
_:vb667059
rdf:rest
_:vb758292
Subject Item
_:vb758292
rdf:first
_:vb667060
rdf:rest
_:vb758293
Subject Item
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rdf:first
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rdf:rest
_:vb758294
Subject Item
_:vb758294
rdf:first
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_:vb758295
Subject Item
_:vb758295
rdf:first
_:vb667063
rdf:rest
_:vb758296
Subject Item
_:vb758296
rdf:first
_:vb667064
rdf:rest
rdf:nil