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Namespace Prefixes

PrefixIRI
n2http://linked.opendata.cz/resource/drugbank/drug/
dctermshttp://purl.org/dc/terms/
n7http://linked.opendata.cz/resource/drugbank/drug/DB05384/identifier/pubchem-compound/
n11http://bio2rdf.org/drugbank:
n9http://linked.opendata.cz/resource/drugbank/drug/DB05384/identifier/drugbank/
admshttp://www.w3.org/ns/adms#
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n8http://linked.opendata.cz/resource/drugbank/drug/DB05384/identifier/chemspider/
n4http://linked.opendata.cz/resource/drugbank/property/
xsdhhttp://www.w3.org/2001/XMLSchema#

Statements

Subject Item
n2:DB05384
rdf:type
n3:Drug
n3:description
Polyacrylic acid is developed by ReProtect. It is a gel that may help both block the spread of sexually transmitted diseases and reduce unwanted pregnancies. The compound, known as BufferGel, is currently in advanced clinical trials for its ability to prevent pregnancy.
n3:generalReferences
# van De Wijgert J, Fullem A, Kelly C, Mehendale S, Rugpao S, Kumwenda N, Chirenje Z, Joshi S, Taha T, Padian N, Bollinger R, Nelson K: Phase 1 trial of the topical microbicide BufferGel: safety results from four international sites. J Acquir Immune Defic Syndr. 2001 Jan 1;26(1):21-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11176265 # Tabet SR, Callahan MM, Mauck CK, Gai F, Coletti AS, Profy AT, Moench TR, Soto-Torres LE, Poindexter III AN, Frezieres RG, Walsh TL, Kelly CW, Richardson BA, Van Damme L, Celum CL: Safety and acceptability of penile application of 2 candidate topical microbicides: BufferGel and PRO 2000 Gel: 3 randomized trials in healthy low-risk men and HIV-positive men. J Acquir Immune Defic Syndr. 2003 Aug 1;33(4):476-83. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12869836
n3:group
investigational
n3:indication
Investigated for use/treatment in contraception and HIV prevention.
owl:sameAs
n11:DB05384
dcterms:title
polyacrylic acid
adms:identifier
n7:6581 n8:6333 n9:DB05384
n3:mechanismOfAction
BufferGel is a microbicidal spermicide that provides sufficient buffering activity to maintain the mild, protective acidity of the vagina in the presence of semen. Sperm are acid-sensitive, so to assure fertility, semen provides a powerful alkalinizing action that abolishes the protective acidity of the vagina for several hours after intercourse. This alkalinizing action of semen also enables acid-sensitive sexually transmitted diseases (STD) pathogens to transmit infection. By blocking this action of semen, BufferGel prevents unwanted pregnancy, and shows promise for prevention of STDs, including HIV/AIDS.
n3:IUPAC-Name
n4:271B425F-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B4265-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B4264-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B4261-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B4262-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B4263-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B425D-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B425B-363D-11E5-9242-09173F13E4C5 n4:271B425E-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B425C-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Acceptor-Count
n4:271B426B-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B426C-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B4266-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B4267-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B4269-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B4268-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B426A-363D-11E5-9242-09173F13E4C5
n3:category
n3:Bioavailability
n4:271B4270-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B4272-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B4273-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B426F-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B426E-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B4271-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B4260-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B426D-363D-11E5-9242-09173F13E4C5