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Namespace Prefixes

PrefixIRI
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n9http://linked.opendata.cz/resource/drugbank/drug/DB01466/identifier/pubchem-compound/
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n15http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
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n4http://linked.opendata.cz/resource/drugbank/property/
n13http://linked.opendata.cz/resource/drugbank/drug/DB01466/identifier/chemspider/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/resource/atc/
n16http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB01466
rdf:type
n3:Drug
n3:description
A narcotic analgesic and antitussive. It is metabolized in the liver by ethylmorphine-N-demethylase and used as an indicator of liver function. It is not marketed in the US but is approved for use in various countries around the world. In the US it is a schedule II drug (single-entity) and schedule III drug (in combination products).
n3:generalReferences
# Aasmundstad TA, Xu BQ, Johansson I, Ripel A, Bjorneboe A, Christophersen AS, Bodd E, Morland J: Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose. Br J Clin Pharmacol. 1995 Jun;39(6):611-20. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7654478 # Xu BQ, Aasmundstad TA, Lillekjendlie B, Bjorneboe A, Christophersen AS, Morland J: Effects of ethanol on ethylmorphine metabolism in isolated rat hepatocytes: characterization by means of a multicompartmental model. Pharmacol Toxicol. 1997 Apr;80(4):171-81. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9140136
n3:group
illicit approved
n3:indication
Ethylmorphine is an analgesic used for pain relief.
owl:sameAs
n6:DB01466 n15:DB01466
dcterms:title
Ethylmorphine
adms:identifier
n9:5359271 n10:46505092 n11:C07537 n12:D07929 n13:4514250 n14:DB01466 n18:Ethylmorphine
n3:mechanismOfAction
Ethylmorphine is metabolized by the liver enzyme cytochrome P450 2D6 to morphine. The precise mechanism of the analgesic action of morphine is unknown. However, specific CNS opiate receptors have been identified and likely play a role in the expression of analgesic effects. Morphine first acts on the mu-opioid receptors. The mechanism of respiratory depression involves a reduction in the responsiveness of the brain stem respiratory centers to increases in carbon dioxide tension and to electrical stimulation. It has been shown that morphine binds to and inhibits GABA inhibitory interneurons. These interneurons normally inhibit the descending pain inhibition pathway. So, without the inhibitory signals, pain modulation can proceed downstream.
n3:synonym
Dionine SID50113064 Ethylmorphine SID144206163 Ethyl morphine
n19:hasConcept
n20:M0007912
n3:IUPAC-Name
n4:271B4D4E-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B4D54-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B4D53-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B4D50-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B4D51-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B4D52-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B4D4C-363D-11E5-9242-09173F13E4C5 n4:271B4D64-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B4D4A-363D-11E5-9242-09173F13E4C5 n4:271B4D4D-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B4D4B-363D-11E5-9242-09173F13E4C5
n16:hasATCCode
n17:R05DA01 n17:S01XA06
n3:H-Bond-Acceptor-Count
n4:271B4D5A-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B4D5B-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B4D55-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B4D56-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B4D58-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B4D57-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B4D59-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
76-58-4
n3:category
n3:Bioavailability
n4:271B4D60-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B4D62-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B4D63-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B4D65-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B4D5F-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B4D5E-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B4D61-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B4D4F-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B4D5C-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B4D5D-363D-11E5-9242-09173F13E4C5