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Namespace Prefixes

PrefixIRI
n31http://www.rxlist.com/cgi/generic3/
n2http://linked.opendata.cz/resource/drugbank/drug/
n17http://linked.opendata.cz/resource/drugbank/drug/DB01128/identifier/national-drug-code-directory/
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n5http://linked.opendata.cz/resource/drugbank/company/
n7http://linked.opendata.cz/resource/drugbank/dosage/
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n11http://linked.opendata.cz/resource/drugbank/drug/DB01128/identifier/chebi/
n28http://bio2rdf.org/drugbank:
n10http://linked.opendata.cz/resource/drugbank/drug/DB01128/identifier/wikipedia/
admshttp://www.w3.org/ns/adms#
n9http://linked.opendata.cz/resource/drugbank/drug/DB01128/identifier/pharmgkb/
n29http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
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rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n24http://linked.opendata.cz/resource/drugbank/medicinal-product/
n13http://linked.opendata.cz/resource/drugbank/drug/DB01128/identifier/bindingdb/
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owlhttp://www.w3.org/2002/07/owl#
n3http://linked.opendata.cz/ontology/drugbank/
n23http://www.drugs.com/cdi/
n4http://linked.opendata.cz/resource/drugbank/property/
n21http://linked.opendata.cz/resource/drugbank/drug/DB01128/identifier/pubchem-substance/
xsdhhttp://www.w3.org/2001/XMLSchema#
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n16http://linked.opendata.cz/resource/drugbank/drug/DB01128/identifier/drugbank/
n15http://linked.opendata.cz/resource/drugbank/drug/DB01128/identifier/iuphar/
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n30http://linked.opendata.cz/resource/atc/
n14http://linked.opendata.cz/resource/drugbank/drug/DB01128/identifier/guide-to-pharmacology/

Statements

Subject Item
n2:DB01128
rdf:type
n3:Drug
n3:description
Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It binds to the androgen receptor.
n3:dosage
n7:271B454F-363D-11E5-9242-09173F13E4C5 n7:271B454E-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:halfLife
5.9 days
n3:indication
For treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.
owl:sameAs
n28:DB01128 n29:DB01128
dcterms:title
Bicalutamide
adms:identifier
n9:PA164746255 n10:Bicalutamide n11:100717 n12:50614 n13:18678 n14:2863 n15:2863 n16:DB01128 n17:0378-7017-93 n18:C08160 n19:D00961 n20:2375 n21:46505386
n3:mechanismOfAction
Bicalutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue.
n3:packager
n5:271B4545-363D-11E5-9242-09173F13E4C5 n5:271B4544-363D-11E5-9242-09173F13E4C5 n5:271B454A-363D-11E5-9242-09173F13E4C5 n5:271B4549-363D-11E5-9242-09173F13E4C5 n5:271B453D-363D-11E5-9242-09173F13E4C5 n5:271B453E-363D-11E5-9242-09173F13E4C5 n5:271B453C-363D-11E5-9242-09173F13E4C5 n5:271B4548-363D-11E5-9242-09173F13E4C5 n5:271B454B-363D-11E5-9242-09173F13E4C5 n5:271B4546-363D-11E5-9242-09173F13E4C5 n5:271B4547-363D-11E5-9242-09173F13E4C5 n5:271B4542-363D-11E5-9242-09173F13E4C5 n5:271B4543-363D-11E5-9242-09173F13E4C5 n5:271B4540-363D-11E5-9242-09173F13E4C5 n5:271B4541-363D-11E5-9242-09173F13E4C5 n5:271B453F-363D-11E5-9242-09173F13E4C5
n3:synonym
Casodex
n25:hasAHFSCode
n26:10-00-00
n3:foodInteraction
Take without regard to meals, at the same time everyday.
n3:proteinBinding
96%
n3:synthesisReference
Nnochiri Ekwuribe, "METHODS OF SYNTHESIZING ACYLANILIDES INCLUDING BICALUTAMIDE AND DERIVATIVES THEREOF." U.S. Patent US20020165406, issued November 07, 2002.
foaf:page
n23:bicalutamide.html n31:bicalutamide.htm
n3:IUPAC-Name
n4:271B4554-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B455A-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B4559-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B4556-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B4557-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B4558-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B456A-363D-11E5-9242-09173F13E4C5 n4:271B4552-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B456C-363D-11E5-9242-09173F13E4C5 n4:271B4550-363D-11E5-9242-09173F13E4C5 n4:271B4553-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B4551-363D-11E5-9242-09173F13E4C5
n3:pKa
n4:271B456D-363D-11E5-9242-09173F13E4C5
n25:hasATCCode
n30:L02BB03
n3:H-Bond-Acceptor-Count
n4:271B4560-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B4561-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B455B-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B455C-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B455E-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B455D-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B455F-363D-11E5-9242-09173F13E4C5
n3:absorption
Bicalutamide is well-absorbed following oral administration, although the absolute bioavailability is unknown.
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
90357-06-5
n3:clearance
* Apparent oral cl=0.32 L/h [Normal Males]
n3:containedIn
n24:271B454C-363D-11E5-9242-09173F13E4C5 n24:271B454D-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B4566-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B4568-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B4569-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B456B-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B4565-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B4564-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B4567-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B4555-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B4562-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B4563-363D-11E5-9242-09173F13E4C5