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Namespace Prefixes

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Statements

Subject Item
n2:DB00396
rdf:type
n6:Drug
n6:description
The major progestational steroid that is secreted primarily by the corpus luteum and the placenta. Progesterone acts on the uterus, the mammary glands, and the brain. It is required in embryo implantation, pregnancy maintenance, and the development of mammary tissue for milk production. Progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids. [PubChem]
n6:dosage
n12:271B4284-363D-11E5-9242-09173F13E4C5 n12:271B4285-363D-11E5-9242-09173F13E4C5 n12:271B4286-363D-11E5-9242-09173F13E4C5 n12:271B4280-363D-11E5-9242-09173F13E4C5 n12:271B4281-363D-11E5-9242-09173F13E4C5 n12:271B4282-363D-11E5-9242-09173F13E4C5 n12:271B4283-363D-11E5-9242-09173F13E4C5 n12:271B427F-363D-11E5-9242-09173F13E4C5 n12:271B4287-363D-11E5-9242-09173F13E4C5
n6:generalReferences
# Allen WM: THE ISOLATION OF CRYSTALLINE PROGESTIN. Science. 1935 Aug 2;82(2118):89-93. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17747122 # Allen WM: Progesterone: how did the name originate? South Med J. 1970 Oct;63(10):1151-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/4922128 # Schumacher M, Guennoun R, Robert F, Carelli C, Gago N, Ghoumari A, Gonzalez Deniselle MC, Gonzalez SL, Ibanez C, Labombarda F, Coirini H, Baulieu EE, De Nicola AF: Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination. Growth Horm IGF Res. 2004 Jun;14 Suppl A:S18-33. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15135772 # Hould FS, Fried GM, Fazekas AG, Tremblay S, Mersereau WA: Progesterone receptors regulate gallbladder motility. J Surg Res. 1988 Dec;45(6):505-12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3184927
n6:group
approved
n6:halfLife
34.8-55.13 hours
n6:indication
For progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea. Also used for the reduction of the incidence of endometrial hyperplasia and the attendant risk of endometrial carcinoma in postmenopausal women receiving estrogen replacement therapy, as well as treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology such as fibroids or uterine cancer.
n6:manufacturer
n11:271B4266-363D-11E5-9242-09173F13E4C5 n11:271B4267-363D-11E5-9242-09173F13E4C5 n11:271B4264-363D-11E5-9242-09173F13E4C5 n11:271B4265-363D-11E5-9242-09173F13E4C5 n11:271B426C-363D-11E5-9242-09173F13E4C5 n11:271B426D-363D-11E5-9242-09173F13E4C5 n11:271B4268-363D-11E5-9242-09173F13E4C5 n11:271B426B-363D-11E5-9242-09173F13E4C5 n11:271B4263-363D-11E5-9242-09173F13E4C5 n11:271B426A-363D-11E5-9242-09173F13E4C5 n11:271B4269-363D-11E5-9242-09173F13E4C5
owl:sameAs
n23:DB00396 n27:DB00396
dcterms:title
Progesterone
adms:identifier
n4:DB00396 n5:1CA n7:PA451123 n8:D00066 n9:0591-3128-79 n26:Progesterone n28:17026 n31:5994 n32:46508968 n33:C00410 n34:5773
n6:mechanismOfAction
Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. In women who have adequate endogenous estrogen, progesterone transforms a proliferative endometrium into a secretory one. Progesterone is essential for the development of decidual tissue and is necessary to increase endometrial receptivity for implantation of an embryo. Once an embryo has been implanted, progesterone acts to maintain the pregnancy. Progesterone also stimulates the growth of mammary alveolar tissue and relaxes uterine smooth muscle. It has little estrogenic and androgenic activity.
n6:packager
n11:271B4260-363D-11E5-9242-09173F13E4C5 n11:271B425D-363D-11E5-9242-09173F13E4C5 n11:271B425E-363D-11E5-9242-09173F13E4C5 n11:271B4253-363D-11E5-9242-09173F13E4C5 n11:271B425F-363D-11E5-9242-09173F13E4C5 n11:271B4254-363D-11E5-9242-09173F13E4C5 n11:271B4251-363D-11E5-9242-09173F13E4C5 n11:271B4252-363D-11E5-9242-09173F13E4C5 n11:271B424F-363D-11E5-9242-09173F13E4C5 n11:271B4250-363D-11E5-9242-09173F13E4C5 n11:271B424D-363D-11E5-9242-09173F13E4C5 n11:271B424E-363D-11E5-9242-09173F13E4C5 n11:271B425B-363D-11E5-9242-09173F13E4C5 n11:271B425C-363D-11E5-9242-09173F13E4C5 n11:271B4259-363D-11E5-9242-09173F13E4C5 n11:271B425A-363D-11E5-9242-09173F13E4C5 n11:271B4257-363D-11E5-9242-09173F13E4C5 n11:271B4258-363D-11E5-9242-09173F13E4C5 n11:271B4262-363D-11E5-9242-09173F13E4C5 n11:271B4255-363D-11E5-9242-09173F13E4C5 n11:271B4256-363D-11E5-9242-09173F13E4C5 n11:271B4261-363D-11E5-9242-09173F13E4C5 n11:271B424B-363D-11E5-9242-09173F13E4C5 n11:271B424C-363D-11E5-9242-09173F13E4C5 n11:271B4249-363D-11E5-9242-09173F13E4C5 n11:271B424A-363D-11E5-9242-09173F13E4C5
n6:patent
n24:5543150 n24:7300664
n6:routeOfElimination
The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the urine and bile. Progesterone metabolites which are excreted in the bile may undergo enterohepatic recycling or may be excreted in the feces. Progesterone metabolites are excreted mainly by the kidneys.
n6:synonym
Progesterona Akrolutin Progesteron Corpus Luteum Hormone 17α-progesterone delta(4)-Pregnene-3,20-dione Gelbkoerperhormon Progestérone Agolutin 4-Pregnene-3,20-dione Crinone Lutogynon Luteohormone (S)-Progesterone Pregn-4-ene-3,20-dione 17alpha-Progesterone (S)-4-Pregnene-3,20-dione Progesterone Progesteronum (S)-Pregn-4-en-3,20-dione
n13:hasAHFSCode
n20:68-32-00
n6:foodInteraction
Increase dietary intake of magnesium, folate, vitamin B6, B12, and/or consider taking a multivitamin. Take with food. Avoid excessive quantities of coffee or tea (Caffeine). Avoid alcohol. Take at the same time everyday.
n6:mixture
n25:271B4248-363D-11E5-9242-09173F13E4C5
n6:proteinBinding
96%-99%
n6:synthesisReference
Nejib M. Nasraoui, Alain Piasco, "Derivatives of 19-nor progesterone; process for producing them and the pharmaceutical compositions incorporating them." U.S. Patent US5223492, issued May, 1971.
n29:hasConcept
n30:M0017672
foaf:page
n16:progesterone.htm n17:pro1670.shtml n21:progesterone.html
n6:IUPAC-Name
n10:271B428C-363D-11E5-9242-09173F13E4C5
n6:InChI
n10:271B4292-363D-11E5-9242-09173F13E4C5
n6:Molecular-Formula
n10:271B4291-363D-11E5-9242-09173F13E4C5
n6:Molecular-Weight
n10:271B428E-363D-11E5-9242-09173F13E4C5
n6:Monoisotopic-Weight
n10:271B428F-363D-11E5-9242-09173F13E4C5
n6:SMILES
n10:271B4290-363D-11E5-9242-09173F13E4C5
n6:Water-Solubility
n10:271B428A-363D-11E5-9242-09173F13E4C5 n10:271B42A2-363D-11E5-9242-09173F13E4C5
n6:logP
n10:271B428B-363D-11E5-9242-09173F13E4C5 n10:271B4288-363D-11E5-9242-09173F13E4C5 n10:271B42A4-363D-11E5-9242-09173F13E4C5
n6:logS
n10:271B4289-363D-11E5-9242-09173F13E4C5 n10:271B42A5-363D-11E5-9242-09173F13E4C5
n13:hasATCCode
n14:G03DA04
n6:H-Bond-Acceptor-Count
n10:271B4298-363D-11E5-9242-09173F13E4C5
n6:H-Bond-Donor-Count
n10:271B4299-363D-11E5-9242-09173F13E4C5
n6:InChIKey
n10:271B4293-363D-11E5-9242-09173F13E4C5
n6:Polar-Surface-Area--PSA-
n10:271B4294-363D-11E5-9242-09173F13E4C5
n6:Polarizability
n10:271B4296-363D-11E5-9242-09173F13E4C5
n6:Refractivity
n10:271B4295-363D-11E5-9242-09173F13E4C5
n6:Rotatable-Bond-Count
n10:271B4297-363D-11E5-9242-09173F13E4C5
n6:absorption
Progesterone absorption is prolonged with an absorption half-life of approximately 25-50 hours.
n6:affectedOrganism
Humans and other mammals
n6:caco2-Permeability
n10:271B42A6-363D-11E5-9242-09173F13E4C5
n6:casRegistryNumber
57-83-0
n6:category
n6:clearance
* 2510 +/- 135 L/day [cycling women]
n6:containedIn
n19:271B4275-363D-11E5-9242-09173F13E4C5 n19:271B4276-363D-11E5-9242-09173F13E4C5 n19:271B4272-363D-11E5-9242-09173F13E4C5 n19:271B4273-363D-11E5-9242-09173F13E4C5 n19:271B4270-363D-11E5-9242-09173F13E4C5 n19:271B4271-363D-11E5-9242-09173F13E4C5 n19:271B426E-363D-11E5-9242-09173F13E4C5 n19:271B426F-363D-11E5-9242-09173F13E4C5 n19:271B427D-363D-11E5-9242-09173F13E4C5 n19:271B427E-363D-11E5-9242-09173F13E4C5 n19:271B427B-363D-11E5-9242-09173F13E4C5 n19:271B427C-363D-11E5-9242-09173F13E4C5 n19:271B4279-363D-11E5-9242-09173F13E4C5 n19:271B427A-363D-11E5-9242-09173F13E4C5 n19:271B4277-363D-11E5-9242-09173F13E4C5 n19:271B4278-363D-11E5-9242-09173F13E4C5 n19:271B4274-363D-11E5-9242-09173F13E4C5
n6:Bioavailability
n10:271B429E-363D-11E5-9242-09173F13E4C5
n6:Ghose-Filter
n10:271B42A0-363D-11E5-9242-09173F13E4C5
n6:MDDR-Like-Rule
n10:271B42A1-363D-11E5-9242-09173F13E4C5
n6:Melting-Point
n10:271B42A3-363D-11E5-9242-09173F13E4C5
n6:Number-of-Rings
n10:271B429D-363D-11E5-9242-09173F13E4C5
n6:Physiological-Charge
n10:271B429C-363D-11E5-9242-09173F13E4C5
n6:Rule-of-Five
n10:271B429F-363D-11E5-9242-09173F13E4C5
n6:Traditional-IUPAC-Name
n10:271B428D-363D-11E5-9242-09173F13E4C5
n6:pKa--strongest-acidic-
n10:271B429A-363D-11E5-9242-09173F13E4C5
n6:pKa--strongest-basic-
n10:271B429B-363D-11E5-9242-09173F13E4C5