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Namespace Prefixes

PrefixIRI
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n21http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/kegg-compound/
n28http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/pdb/
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n24http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/drugbank/
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n18http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/
n23http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/chemspider/
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n16http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/wikipedia/
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n15http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/pharmgkb/
n5http://linked.opendata.cz/ontology/sukl/drug/

Statements

Subject Item
n2:DB00368
rdf:type
n3:Drug
n3:description
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. [PubChem]
n3:dosage
n17:271B617F-363D-11E5-9242-09173F13E4C5
n3:group
approved
n3:indication
Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
n3:manufacturer
n9:271B6178-363D-11E5-9242-09173F13E4C5
owl:sameAs
n11:DB00368 n18:DB00368
dcterms:title
Norepinephrine
adms:identifier
n15:PA450649 n16:Norepinephrine n19:18357 n21:C00547 n22:D00076 n23:388394 n24:DB00368 n25:439260 n26:46506201 n27:0409-3375-04 n28:LNR
n3:mechanismOfAction
Norepinephrine functions as a peripheral vasoconstrictor by acting on alpha-adrenergic receptors. It is also an inotropic stimulator of the heart and dilator of coronary arteries as a result of it's activity at the beta-adrenergic receptors.
n3:packager
n9:271B6175-363D-11E5-9242-09173F13E4C5 n9:271B6176-363D-11E5-9242-09173F13E4C5 n9:271B6173-363D-11E5-9242-09173F13E4C5 n9:271B6174-363D-11E5-9242-09173F13E4C5 n9:271B6171-363D-11E5-9242-09173F13E4C5 n9:271B6172-363D-11E5-9242-09173F13E4C5 n9:271B6170-363D-11E5-9242-09173F13E4C5 n9:271B6177-363D-11E5-9242-09173F13E4C5
n3:synonym
Noradrenaline 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol (R)-4-(2-amino-1-Hydroxyethyl)-1,2-benzenediol (-)-Arterenol Norepinephrinum Arterenol (-)-Noradrenaline Norepinefrina (R)-Norepinephrine (-)-Norepinephrine (R)-(-)-Norepinephrine L-Norepinephrine L-noradrenaline Norepinephrine
n3:toxicity
In high dose and especially when it is combined with other vasopressors, it can lead to limb ischemia and limb death.
n5:hasAHFSCode
n6:12-12-12 n6:68-12-00
n29:hasConcept
n30:M0014964
foaf:page
n8:norepinephrine.htm n31:norepinephrine.html
n3:IUPAC-Name
n4:271B6184-363D-11E5-9242-09173F13E4C5
n3:InChI
n4:271B618A-363D-11E5-9242-09173F13E4C5
n3:Molecular-Formula
n4:271B6189-363D-11E5-9242-09173F13E4C5
n3:Molecular-Weight
n4:271B6186-363D-11E5-9242-09173F13E4C5
n3:Monoisotopic-Weight
n4:271B6187-363D-11E5-9242-09173F13E4C5
n3:SMILES
n4:271B6188-363D-11E5-9242-09173F13E4C5
n3:Water-Solubility
n4:271B6182-363D-11E5-9242-09173F13E4C5
n3:logP
n4:271B6183-363D-11E5-9242-09173F13E4C5 n4:271B6180-363D-11E5-9242-09173F13E4C5 n4:271B619B-363D-11E5-9242-09173F13E4C5
n3:logS
n4:271B6181-363D-11E5-9242-09173F13E4C5
n3:pKa
n4:271B619C-363D-11E5-9242-09173F13E4C5
n5:hasATCCode
n12:C01CA03
n3:H-Bond-Acceptor-Count
n4:271B6190-363D-11E5-9242-09173F13E4C5
n3:H-Bond-Donor-Count
n4:271B6191-363D-11E5-9242-09173F13E4C5
n3:InChIKey
n4:271B618B-363D-11E5-9242-09173F13E4C5
n3:Polar-Surface-Area--PSA-
n4:271B618C-363D-11E5-9242-09173F13E4C5
n3:Polarizability
n4:271B618E-363D-11E5-9242-09173F13E4C5
n3:Refractivity
n4:271B618D-363D-11E5-9242-09173F13E4C5
n3:Rotatable-Bond-Count
n4:271B618F-363D-11E5-9242-09173F13E4C5
n3:affectedOrganism
Humans and other mammals
n3:casRegistryNumber
51-41-2
n3:category
n3:containedIn
n20:271B617D-363D-11E5-9242-09173F13E4C5 n20:271B617E-363D-11E5-9242-09173F13E4C5 n20:271B617B-363D-11E5-9242-09173F13E4C5 n20:271B617C-363D-11E5-9242-09173F13E4C5 n20:271B6179-363D-11E5-9242-09173F13E4C5 n20:271B617A-363D-11E5-9242-09173F13E4C5
n3:Bioavailability
n4:271B6196-363D-11E5-9242-09173F13E4C5
n3:Ghose-Filter
n4:271B6198-363D-11E5-9242-09173F13E4C5
n3:MDDR-Like-Rule
n4:271B6199-363D-11E5-9242-09173F13E4C5
n3:Melting-Point
n4:271B619A-363D-11E5-9242-09173F13E4C5
n3:Number-of-Rings
n4:271B6195-363D-11E5-9242-09173F13E4C5
n3:Physiological-Charge
n4:271B6194-363D-11E5-9242-09173F13E4C5
n3:Rule-of-Five
n4:271B6197-363D-11E5-9242-09173F13E4C5
n3:Traditional-IUPAC-Name
n4:271B6185-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-acidic-
n4:271B6192-363D-11E5-9242-09173F13E4C5
n3:pKa--strongest-basic-
n4:271B6193-363D-11E5-9242-09173F13E4C5