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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Chidamide
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Chidamide
UMLS_CUI
  • C2932486
CAS_Registry
  • 743420-02-2
PDQ_Open_Trial_Search_ID
  • 702501
PDQ_Closed_Trial_Search_ID
  • 702501
FULL_SYN
  • N-(2-amino-5-fluorine benzyl)-4-[N-(pyridine-3-acrylyl) ammonia methyl] BenzamideSNNCI
  • CS055CNNCI
  • N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamideSNNCI
  • HBI-8000CNNCI
  • ChidamidePTNCI
DEFINITION
  • An orally bioavailable benzamide-type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10, with potential antineoplastic activity. Chidamide binds to and inhibits HDACs, leading to an increase of acetylation levels of histone proteins. This agent also inhibits the expression of kinases in the PI3K/Akt and MAPK/Ras signaling pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis. This may inhibit tumor cell proliferation in susceptible tumor cells. HDACs, a class of enzymes that deacetylate chromatin histone proteins, are upregulated in many tumor types and play key roles in gene expression. Compared to some other benzamide-type HDAC inhibitors, chidamide is more stable, more resistant to degradation and has a longer half-life.NCI
code
  • C97263
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