About: Palifosfamide Tromethamine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Palifosfamide Tromethamine
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Palifosfamide Tromethamine
NCI_META_CUI
  • CL428169
PDQ_Open_Trial_Search_ID
  • 689807
PDQ_Closed_Trial_Search_ID
  • 689807
FULL_SYN
  • Palifosfamide TromethaminePTNCI
  • Palifosfamide TrisSYNCI
DEFINITION
  • A synthetic mustard compound of the tromethamine (tris) salt of palifosfamide (Isophosphamide mustard), with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide irreversibly alkylates and crosslinks DNA through GC base pairs, resulting in irreparable 7-atom interstrand crosslinks. This leads to an inhibition of DNA replication and ultimately cell death. Unlike ifosfamide, this agent is not metabolized to acrolein or chloroacetaldehyde, metabolites associated with bladder and CNS toxicities. In addition, because palifosfamide does not require activation by aldehyde dehydrogenase, it may overcome the tumor resistance seen with ifosfamide. Stabilization with tris instead of lysine further increases stability and may further decrease nephrotoxicity.NCI
code
  • C95703
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