About: Triazene Derivative TriN2755     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Triazene Derivative TriN2755
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Triazene Derivative TriN2755
NCI_META_CUI
  • CL426697
PDQ_Open_Trial_Search_ID
  • 691486
PDQ_Closed_Trial_Search_ID
  • 691486
FULL_SYN
  • Triazene Derivative TriN2755PTNCI
  • TriN2755CNNCI
DEFINITION
  • A synthetic triazene derivative with antineoplastic activity. Upon metabolic activation via N-demethylation, TriN2755 is converted into highly reactive carbocations that can alkylate DNA and other macromolecules, thereby resulting in DNA cross links, inhibiting DNA replication and repair, and subsequently inducing apoptosis. This agent has high hydrophilicity and photostability and shows a favorable toxicity profile over the other triazenes.NCI
code
  • C95208
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