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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Thiarabine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Thiarabine
UMLS_CUI
  • C0915968
PDQ_Open_Trial_Search_ID
  • 675426
PDQ_Closed_Trial_Search_ID
  • 675426
FULL_SYN
  • 4-thio-araCABNCI
  • ThiarabinePTNCI
DEFINITION
  • A analog of antimetabolite cytarabine (ara-C), with potential antineoplastic activity. Upon administration, thiarabine (T-araC) is phosphorylated to the triphosphate form T-araCTP and competes with cytidine for incorporation into DNA. This results in an inhibition of DNA replication and RNA synthesis, chain termination and may eventually decrease tumor cell proliferation. Compared to ara-C, T-araC appears to have a longer half-life and has a higher efficacy.NCI
code
  • C92589
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