About: Malaria Pathway

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Malaria Pathway
rdfs:subClassOf	Infectious Disease Pathway
Semantic_Type	Functional Concept
Preferred_Name	Malaria Pathway
UMLS_CUI	C2984572
KEGG_ID	hsa05144
ALT_DEFINITION	Plasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop into the merozoite form. Sporozoite invasion of hepatocytes is mediated by parasite surface protein like CSP. Subsequent infection into red blood cells (RBCs) by merozoites causes malaria disease via aberrant cytokine production and sequestration of parasite-infected red blood cells (pRBCs) to host endothelium. Microvasculature sequestration in the brain brings about cerebral malaria that can result in death or persisting neurological impairment. PfEMP1 has been suggested as the key adhesive molecule of pRBCs.KEGG
FULL_SYN	Plasmodium sp. Infection PathwaySYNCI Malaria PathwayPTNCI Plasmodium Infection PathwaySYNCI MalariaPTKEGG
code	C91807
is someValuesFrom of	nodeID://b652113 nodeID://b679687 nodeID://b685199 nodeID://b686145 nodeID://b695440 nodeID://b704483 nodeID://b709743 nodeID://b709749 nodeID://b716481 nodeID://b716493 nodeID://b722754 nodeID://b722766

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