About: Systemic Lupus Erythematosus Pathway     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Systemic Lupus Erythematosus Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Systemic Lupus Erythematosus Pathway
UMLS_CUI
  • C2984317
KEGG_ID
  • hsa05322
ALT_DEFINITION
  • Systemic lupus erythematosus (SLE) is characterized by circulating IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components. Immune complexes comprising autoantibody and self-antigen is deposited particularly in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc-gamma-R-mediated neutrophil and macrophage activation. Activation of complement leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases.KEGG
FULL_SYN
  • SLE PathwaySYNCI
  • Systemic Lupus Erythematosus PathwayPTNCI
  • Systemic lupus erythematosusPTKEGG
code
  • C91508
is someValuesFrom of
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