About: Proximal Tubule Bicarbonate Reclamation Pathway     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Proximal Tubule Bicarbonate Reclamation Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Proximal Tubule Bicarbonate Reclamation Pathway
UMLS_CUI
  • C2984305
KEGG_ID
  • hsa04964
ALT_DEFINITION
  • One of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "new HCO3(-)" for regulating blood pH. In the tubular lumen, filtered HCO3(-) combines with H(+) in a reaction catalyzed by CA IV. The CO2 thus produced rapidly diffuses into the tubular cells and is combined with water to produce intracellular H(+) and HCO3(-), catalyzed by soluble cytoplasmic CA II. HCO3(-) is then cotransported with Na(+) into blood via the NBC-1. The intracellular H(+) produced by CA II is secreted into the tubular lumen predominantly via the NHE-3. The PT creates the "new HCO3(-)" by taking glutamine and metabolizing it to two molecules each of NH4(+) and HCO3(-). The NH4(+) is excreted into the tubular lumen, and the HCO3(-), which is "new HCO3(-)," is returned to the blood, where it replaces the HCO3(-) lost earlier in the titration of nonvolatile acids.KEGG
FULL_SYN
  • Proximal Tubule Bicarbonate Reclamation PathwayPTNCI
  • Proximal tubule bicarbonate reclamationPTKEGG
code
  • C91494
is someValuesFrom of
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