About: Smoothened Antagonist LEQ506     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Smoothened Antagonist LEQ506
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Smoothened Antagonist LEQ506
NCI_META_CUI
  • CL421477
PDQ_Open_Trial_Search_ID
  • 671850
PDQ_Closed_Trial_Search_ID
  • 671850
FULL_SYN
  • Smoothened Antagonist LEQ506PTNCI
  • LEQ506CNNCI
DEFINITION
  • An orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway, thereby inhibiting tumor cell growth. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Dysregulated activation of Hh pathway signaling and uncontrolled cellular proliferation, as is observed in a variety of cancers, may be associated with mutations in the Hh-ligand cell surface receptor Smo.NCI
code
  • C91089
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