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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Triamcinolone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Triamcinolone
NSC_Code
  • 13397
UMLS_CUI
  • C0040864
CAS_Registry
  • 124-94-7
FDA_UNII_Code
  • 1ZK20VI6TY
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied for the prevention of nonmelanoma skin cancer. It is an anti-inflammatory drug that is applied to the skin to relieve irritation, rashes, and infections. It belongs to the family of drugs called topical corticosteroids.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39275
PDQ_Closed_Trial_Search_ID
  • 39275
Chemical_Formula
  • C21H27FO6
Legacy_Concept_Name
  • Triamcinolone
CHEBI_ID
  • CHEBI:9667
FULL_SYN
  • TRIAMCINOLONEPTFDA1ZK20VI6TY
  • TriamcinolonePTNCI
  • TriamcinoloneSYDTPNSC0013397
  • triamcinolonePTNCI-GLOSSCDR0000045206
  • (11beta,16alpha)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dioneSNNCI
  • (11beta,16alpha)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dionePTDCP07584
  • AristocortSYDTPNSC0013397
  • AristocortBRNCI
DEFINITION
  • A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to translocation of the ligand-receptor complex to the nucleus and induces expression of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, pro-inflammatory cytokine production, including interleukin (IL)-1and IL-6, and the activation of cytotoxic T-lymphocytes is also inhibited. T-cells are prevented from making IL-2 and proliferating. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis through increasing Ikappa-B expression and curtailing activation of nuclear factor (NF)kappa-B.NCI
code
  • C901
sameAs
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