About: Melphalan Hydrochloride/Sulfobutyl Ether Beta-Cyclodextrin Complex     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Melphalan Hydrochloride/Sulfobutyl Ether Beta-Cyclodextrin Complex
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Melphalan Hydrochloride/Sulfobutyl Ether Beta-Cyclodextrin Complex
NCI_META_CUI
  • CL412380
PDQ_Open_Trial_Search_ID
  • 649061
PDQ_Closed_Trial_Search_ID
  • 649061
FULL_SYN
  • Melphalan Hydrochloride/Sulfobutyl Ether Beta-Cyclodextrin ComplexPTNCI
  • Captisol-enabled Melphalan IVBRNCI
DEFINITION
  • A propylene glycol-free intravenous formulation containing the hydrochloride salt of the nitrogen mustard phenylalanine derivative melphalan complexed with polyanionic sulfobutyl ether beta-cyclodextrin (SBE-CD) with potential antineoplastic activity. Upon administration, melphalan is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA; RNA and proteins may also be alkylated. Subsequently, RNA transcription and protein synthesis are inhibited, resulting in cell growth arrest. The addition of sulfobutyl ether beta-cyclodextrin to the formulation improves the solubility, stability and ease of use of melphalan; cyclodextrins are cyclic dextrins derived from starch.NCI
code
  • C84878
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