About: Progesterone Vaginal Insert     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Progesterone Vaginal Insert
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Progesterone Vaginal Insert
UMLS_CUI
  • C1961966
PDQ_Open_Trial_Search_ID
  • 648749
PDQ_Closed_Trial_Search_ID
  • 648749
FULL_SYN
  • Progesterone Vaginal InsertPTNCI
  • EndometrinBRNCI
DEFINITION
  • A tablet preparation formulated for vaginal administration containing a micronized synthetic form of the endogenous steroid hormone progesterone with progesterone activity. Upon vaginal insertion, progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors. This agent exerts inhibitory effects on estrogen by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites. Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy.NCI
code
  • C84874
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