About: Pivampicillin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pivampicillin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pivampicillin
UMLS_CUI
  • C0032032
CAS_Registry
  • 33817-20-8
FDA_UNII_Code
  • 0HLM346LL7
Contributing_Source
  • FDA
Chemical_Formula
  • C22H29N3O6S
CHEBI_ID
  • CHEBI:8255
FULL_SYN
  • PIVAMPICILLINPTFDA0HLM346LL7
  • PivampicillinPTNCI
DEFINITION
  • A semisynthetic, orally active pivalate ester of ampicillin with antibacterial activity. Upon absorption, pivampicillin is hydrolyzed into its active form ampicillin by esterases. Ampicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.NCI
code
  • C84068
sameAs
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