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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Spironolactone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Spironolactone
NSC_Code
  • 150399
UMLS_CUI
  • C0037982
CAS_Registry
  • 52-01-7
FDA_UNII_Code
  • 27O7W4T232
Contributing_Source
  • FDA
ALT_DEFINITION
  • A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39444
PDQ_Closed_Trial_Search_ID
  • 39444
Chemical_Formula
  • C24H32O4S
Legacy_Concept_Name
  • Spironolactone
CHEBI_ID
  • CHEBI:9241
FULL_SYN
  • 17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, AcetateSNNCI
  • SPIRONOLACTONEPTFDA27O7W4T232
  • 17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, AcetatePTDCP07605
  • SpironolactonePTNCI
  • SPLABNCI
  • SpironolactoneSYDTPNSC0150399
  • SC 9420CNNCI
  • AldactoneSYDTPNSC0150399
  • AldactoneSYNCI
DEFINITION
  • A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. (NCI04)NCI
code
  • C840
sameAs
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