About: Mespirenone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Mespirenone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Mespirenone
UMLS_CUI
  • C0066029
CAS_Registry
  • 87952-98-5
FDA_UNII_Code
  • E91TME2I23
Contributing_Source
  • FDA
Chemical_Formula
  • C25H30O4S
FULL_SYN
  • MespirenonePTNCI
  • MESPIRENONEPTFDAE91TME2I23
DEFINITION
  • A spironolactone derivative and aldosterone antagonist with diuretic activity. Mespirenone, after in vivo metabolization, inhibits aldosterone synthase (steroid 18-hydroxylase), thereby preventing the synthesis of aldosterone in addition to the synthesis of other mineralocorticoids. The blockade of aldosterone synthesis results in increased sodium and water excretion while reducing potassium excretion within the kidney. Mespirenone has a short half-life and is metabolized completely into active metabolites.NCI
code
  • C83938
http://linked.open...y/mesh/hasConcept
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