About: HDAC Inhibitor CHR-2845     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • HDAC Inhibitor CHR-2845
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • HDAC Inhibitor CHR-2845
NCI_META_CUI
  • CL388477
PDQ_Open_Trial_Search_ID
  • 633696
PDQ_Closed_Trial_Search_ID
  • 633696
Legacy_Concept_Name
  • HDAC_Inhibitor_CHR-2845
FULL_SYN
  • HDAC Inhibitor CHR-2845PTNCI
  • Histone Deacetylase Inhibitor CHR-2845SYNCI
  • CHR-2845CNNCI
DEFINITION
  • A hydroxamic acid-derived histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. CHR-2845 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in chromatin remodeling, inhibition of tumor oncogene transcription, inhibition of tumor cell division, and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins; this agent may specifically target HDACs in cells of the monocyte-macrophage lineage.NCI
code
  • C82690
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