About: Deslorelin Acetate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Deslorelin Acetate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Deslorelin Acetate
UMLS_CUI
  • C0378714
CAS_Registry
  • 82318-06-7
FDA_UNII_Code
  • 679007NR5C
Contributing_Source
  • FDA
Chemical_Formula
  • C64H83N17O12.C2H4O2
Legacy_Concept_Name
  • Deslorelin_Acetate
FULL_SYN
  • 6-D-Tryptophan-9-(N-Ethyl-L-Prolinamide)-1-9-Luteinizing Hormone-Releasing Factor (Swine) AcetateSYNCI
  • 5-Oxo-L-Prolyl-L-Histidyl-L-Tryptophyl-L-Seryl-L-Tyrosyl-D-Tryptophyl-L-Leucyl-L-Arginyl-N-Ethyl-L-Prolinamide AcetateSYNCI
  • Deslorelin AcetatePTNCI
  • DESLORELIN ACETATEPTFDA679007NR5C
DEFINITION
  • A synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI04)NCI
code
  • C82600
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