About: Zoledronic Acid Anhydrous     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Zoledronic Acid Anhydrous
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Zoledronic Acid Anhydrous
UMLS_CUI
  • C2700334
CAS_Registry
  • 118072-93-8
FDA_UNII_Code
  • 70HZ18PH24
Contributing_Source
  • FDA
Chemical_Formula
  • C5H10N2O7P2
Legacy_Concept_Name
  • Zolendronic_Acid_Anhydrous
CHEBI_ID
  • CHEBI:46557
FULL_SYN
  • Zoledronic Acid AnhydrousPTNCI
  • ZOLEDRONIC ACID ANHYDROUSPTFDA70HZ18PH24
DEFINITION
  • Anhydrous form of a synthetic imidazole third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix.NCI
code
  • C80120
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