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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Saridegib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Saridegib
UMLS_CUI
  • C2703211
CAS_Registry
  • 1037210-93-7
FDA_UNII_Code
  • JT96FPU35X
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 616875
PDQ_Closed_Trial_Search_ID
  • 616875
Chemical_Formula
  • C29H48N2O3S
Legacy_Concept_Name
  • Smoothened_Antagonist_IPI-926
FULL_SYN
  • IP9 Free BaseSYNCI
  • IPI-926 Free BaseSYNCI
  • FIN-5CNNCI
  • SARIDEGIBPTFDAJT96FPU35X
  • Smoothened Antagonist IPI-926SYNCI
  • IPI-926CNNCI
  • SaridegibPTNCI
DEFINITION
  • An orally bioavailable, cyclopamine-derived inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, Saridegib binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH); inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations. The Hh signaling pathway plays an important role in proliferation of neuronal precursor cells in the developing cerebellum and other tissues.NCI
code
  • C80063
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