About: Cyclosporine Ophthalmic Emulsion     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Cyclosporine Ophthalmic Emulsion
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cyclosporine Ophthalmic Emulsion
UMLS_CUI
  • C1170584
PDQ_Open_Trial_Search_ID
  • 614830
PDQ_Closed_Trial_Search_ID
  • 614830
Legacy_Concept_Name
  • Cyclosporine_Ophthalmic_Emulsion
FULL_SYN
  • Cyclosporine Ophthalmic EmulsionPTNCI
  • RestasisBRNCI
DEFINITION
  • An topical ophthalmic formulation containing cyclosporine, an undecapeptide produced by the fungus Beauveria nivea, with immunosuppressant and anti-inflammatory activities. The exact therapeutic mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release.NCI
code
  • C80051
http://linked.open...y/mesh/hasConcept
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