About: Quinine

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Quinine
rdfs:subClassOf	ANTIMALARIALS nodeID://b705905 nodeID://b705906 nodeID://b705907
Has_Salt_Form	QUININE SULFATE Quinine Glycerophosphate Quinine Hydrochloride
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Quinine
NSC_Code	192949
UMLS_CUI	C0034417
CAS_Registry	130-95-0
FDA_UNII_Code	A7V27PHC7A
Contributing_Source	FDA
ALT_DEFINITION	An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.MSH2002_06_01
PDQ_Open_Trial_Search_ID	41253
PDQ_Closed_Trial_Search_ID	41253
Chemical_Formula	C20H24N2O2
Legacy_Concept_Name	Quinine
CHEBI_ID	CHEBI:15854
FULL_SYN	QUININEPTFDAA7V27PHC7A QUININESYDTPNSC0005362 QUINABNCI QuininePTNCI (-)-QuinineSYDTPNSC0192949
DEFINITION	A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)NCI
code	C794
sameAs	QUININE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0018346
is someValuesFrom of	nodeID://b662612 nodeID://b662777 nodeID://b666470 nodeID://b666478 nodeID://b701494
is Has_Free_Acid_Or_Base_Form of	QUININE SULFATE Quinine Glycerophosphate Quinine Hydrochloride
is sameAs of	QUININE QUININE

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