About: HDAC Inhibitor CHR-3996     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • HDAC Inhibitor CHR-3996
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • HDAC Inhibitor CHR-3996
UMLS_CUI
  • C2703120
PDQ_Open_Trial_Search_ID
  • 600512
PDQ_Closed_Trial_Search_ID
  • 600512
Legacy_Concept_Name
  • HDAC_Inhibitor_CHR-3996
FULL_SYN
  • HDAC Inhibitor CHR-3996PTNCI
  • Histone Deacetylase Inhibitor CHR-3996SYNCI
  • CHR-3996CNNCI
DEFINITION
  • An orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor CHR-3996 inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events may result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins.NCI
code
  • C78475
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