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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Alestramustine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Alestramustine
UMLS_CUI
  • C2697985
CAS_Registry
  • 139402-18-9
FDA_UNII_Code
  • 81U8A51CHK
Contributing_Source
  • FDA
Chemical_Formula
  • C26H36Cl2N2O4
Legacy_Concept_Name
  • Alestramustine
FULL_SYN
  • ALESTRAMUSTINEPTFDA81U8A51CHK
  • AlestramustinePTNCI
DEFINITION
  • The l-alanine ester form of estramustine, a combination of the nitrogen mustard normustine coupled via a carbamate to estradiol, with antineoplastic activity. Upon conversion of alestramustine to estramustine, estramustine binds to microtubule-associated proteins (MAPs) and beta tubulin, thereby interfering with microtubule dynamics and leading to microtubule disassembly and cell cyle arrest. Due to the estrogen moiety, this agent is able to selectively bind to and be taken up by estrogen receptor-positive cells.NCI
code
  • C77370
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