About: Primaquine Phosphate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Primaquine Phosphate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Primaquine Phosphate
NSC_Code
  • 27296
UMLS_CUI
  • C0033128
CAS_Registry
  • 63-45-6
FDA_UNII_Code
  • H0982HF78B
Contributing_Source
  • FDA
ALT_DEFINITION
  • An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizonticide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopia, 30th ed, p404)MSH2002_06_01
Chemical_Formula
  • C15H21N3O.2H3O4P
Legacy_Concept_Name
  • Primaquine
FULL_SYN
  • PRIMAQUINE PHOSPHATEPTFDAH0982HF78B
  • Primaquine PhosphatePTNCI
DEFINITION
  • The phosphate salt form of primaquine, a synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism of action is unclear, primaquine bind to and alter the properties of protozoal DNA. This agent eliminates tissue (exo-erythrocytic) malarial infection, preventing the development of the erythrocytic forms of the parasite which are responsible for relapses in Plasmodium vivax and ovale malaria. Primaquine is active against late hepatic stages (hypnozoites, schizonts).NCI
code
  • C771
sameAs
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