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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Prednimustine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Prednimustine
NSC_Code
  • 134087
  • 171345
UMLS_CUI
  • C0032949
CAS_Registry
  • 29069-24-7
FDA_UNII_Code
  • 9403SIO2S8
Contributing_Source
  • FDA
ALT_DEFINITION
  • Ester of CHLORAMBUCIL and PREDNISOLONE used as a combination alkylating agent and synthetic steroid to treat various leukemias and other neoplasms. It causes gastrointestinal and bone marrow toxicity.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39560
PDQ_Closed_Trial_Search_ID
  • 39560
Chemical_Formula
  • C35H45Cl2NO6
Legacy_Concept_Name
  • Prednimustine
FULL_SYN
  • PREDNIMUSTINEPTFDA9403SIO2S8
  • PrednimustinePTNCI
  • PrednimustineSYDTPNSC0171345
  • (11beta-21-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]-11,17-dihydroxypregna-1,4-diene-3,20-dioneSNNCI
  • Leo 1031SYDTPNSC0171345
  • SterecytSYDTPNSC0171345
  • LEO-1031CNNCI
  • SterecytFBNCI
  • 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-[4-[p-[bis(3-chloroethyl)amino]phenyl]butyrate]SNNCI
  • StereocytFBNCI
  • Chlorambucil Prednisolone EsterSYNCI
DEFINITION
  • The prednisolone ester of chlorambucil and nitrogen mustard alkylating agent with antineoplastic activity. Prednimustine itself is not cytotoxic, however, it becomes cytotoxic upon hydrolysis by serum esterases to chlorambucil. Therefore, the increased potency of prednimustine is linked to the prolonged availability of free chlorambucil.NCI
code
  • C768
sameAs
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