About: Alvespimycin Hydrochloride

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About: Alvespimycin Hydrochloride Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Alvespimycin Hydrochloride
rdfs:subClassOf	Geldanamycin Analogue
Has_Free_Acid_Or_Base_Form	Alvespimycin
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Alvespimycin Hydrochloride
UMLS_CUI	C2350808
CAS_Registry	467214-21-7
FDA_UNII_Code	612K359T69
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	378203
PDQ_Closed_Trial_Search_ID	378203
Chemical_Formula	C32H48N4O8.ClH
Legacy_Concept_Name	Alvespimycin_Hydrochloride
FULL_SYN	17-DMAG HClABNCI Geldanamycin,17-demethoxy-17-((2-(dimethylamino)ethyl)amino)-, MonohydrochlorideSNNCI Alvespimycin HydrochloridePTNCI KOS-1022CNNCI ALVESPIMYCIN HYDROCHLORIDEPTFDA612K359T69 BMS-826476CNNCI
DEFINITION	The hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.NCI
code	C76665
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0523467
is Has_Salt_Form of	Alvespimycin

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