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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Dovitinib
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Dovitinib
UMLS_CUI
  • C2699806
CAS_Registry
  • 405169-16-6
FDA_UNII_Code
  • I35H55G906
Contributing_Source
  • FDA
Chemical_Formula
  • C21H21FN6O
Legacy_Concept_Name
  • Dovitinib
FULL_SYN
  • DOVITINIBPTFDAI35H55G906
  • DovitinibPTNCI
DEFINITION
  • A benzimidazole-quinolinone compound and receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Dovitinib binds to and inhibits the phosphorylation of type III-V RTKs, such as vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) that promote tumor cell proliferation and survival in certain cancer cells. In addition, this agent also inhibits other members of the RTK superfamily, including fibroblast growth factor receptor 1 and 3, FMS-like tyrosine kinase 3, stem cell factor receptor (c-KIT), and colony stimulating factor receptor 1. This may further lead to a reduction of cellular proliferation and angiogenesis, and an induction of tumor cell apoptosis.NCI
code
  • C76199
is Has_Free_Acid_Or_Base_Form of
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