About: Topixantrone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Topixantrone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Topixantrone
UMLS_CUI
  • C1528075
CAS_Registry
  • 156090-18-5
FDA_UNII_Code
  • R40RXC296C
Contributing_Source
  • FDA
Chemical_Formula
  • C21H26N6O2
Legacy_Concept_Name
  • Topixantrone
FULL_SYN
  • TOPIXANTRONEPTFDAR40RXC296C
  • TopixantronePTNCI
  • Indazolo(4,3-gh)isoquinolin-6(2H)-one, 5-((2-(dimethylamino)ethyl)amino)-2-(2-((2-hydroxyethyl)amino)ethyl)-SNNCI
  • BBR 3576CNNCI
DEFINITION
  • A 9-aza-anthrapyrazole antineoplastic antibiotic. Topixantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Compared to other DNA intercalators, this agent shows minimal cardiotoxicity.NCI
code
  • C75124
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