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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Alvocidib
rdfs:subClassOf
Has_Salt_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Alvocidib
UMLS_CUI
  • C0174903
CAS_Registry
  • 146426-40-6
FDA_UNII_Code
  • 45AD6X575G
Contributing_Source
  • FDA
Chemical_Formula
  • C21H20ClNO5
Legacy_Concept_Name
  • Alvocidib_Freebase
FULL_SYN
  • AlvocidibPTDCP31731
  • FlavopiridolSYNCI
  • -)cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-oneSNNCI
  • flavopiridolPTNCI-GLOSSCDR0000045419
  • ALVOCIDIBPTFDA45AD6X575G
  • Alvocidib FreebaseSYNCI
  • AlvocidibPTNCI
  • alvocidibPTNCI-GLOSSCDR0000630913
DEFINITION
  • The free base form of a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.NCI
code
  • C74940
http://linked.open...y/mesh/hasConcept
is Has_Free_Acid_Or_Base_Form of
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